SARS-CoV-2 ve diğer koronavirüsler: büyük fizik makinelerine dayalı gelişmiş karakterizasyonun yenilikçi yaklaşımları

Author :  

DOI : 10.29228/JCHAR.52780
Year-Number: 2021-3
Yayımlanma Tarihi: 2021-10-23 14:48:17.0
Language : English
Konu : Physical Characterization
Number of pages: 137-147
Mendeley EndNote Alıntı Yap

Abstract

Hızla büyüyen koronavirüs hastalığı (COVID-19) salgınından sorumlu patojen olan yeni koronavirüs SARS-CoV-2, son derece yüksek bulaşıcılığı ve potansiyel pnömoni geliştirme riski nedeniyle yaygın endişelere ve korkuya neden oluyor. Küresel araştırma çabaları, devam eden pandemi ile mücadele etmek için etkili ilaçlar veya aşılar geliştirmek için virüs patogenezinin moleküler mekanizmasını araştırmaya adanmıştır. SARS-CoV-2 proteinleriyle ilgili veya viral enfeksiyonların tedavisi için potansiyel ilaçların test edilmesiyle ilgili çeşitli deneyler şu anda yürütülmektedir. Bu derlemede, Synchrotron radyasyonu ve Nötron ışınlarını kullanan büyük fizik makinelerine dayalı ileri karakterizasyon için yenilikçi yaklaşımlar tartışılmaktadır.

Keywords

Abstract

The novel coronavirus SARS-CoV-2, the pathogen responsible for the rapidly growing outbreak of coronavirus disease (COVID-19), is causing widespread concerns and fear, due to its extremely high contagiousness and the potential risk of developing pneumonia. Global research efforts have been devoted to investigating the molecular mechanism of virus pathogenesis, in order to develop effective drugs or vaccines to tackle the on-going pandemic. Several experiments related to SARS-CoV-2 proteins or for testing potential drugs for the treatment of viral infections are currently being carried out. In the present review, innovative approaches for advanced characterization based on large machines of physics, making use of Synchrotron radiation and Neutron beams, are discussed.

Keywords

Kaynakça

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