This study was aimed at preparation and comparison of the physiochemical properties of a locally prepared microcrystalline cellulose obtained from dried stem pulp chips of sugarcane (Saccharum officinarum) coded SO-MCC and compared with a commercial grade (Avicel PH 102). SO-MCC was prepared from a-cellulose derived by alkaline hydrolysis from dried sugarcane stem chips, bleached with sodium hypochlorite and treated with 2.5N hydrochloric acid. The MCC were identified by BP (2009) method. The comparative physicochemical properties evaluated include: DSC, pH, mean particles diameter, true, bulk and tapped densities, angle of repose, Hausner’s quotient, compressibility index, porosity, hydration, swelling and moisture sorption capacities. The results obtained from these tests are: pH (7.5), mean particle diameter (239), true, bulk and tapped densities (1.54, 0.464, 0.617), angle of repose (34.70), Hausner’s quotient (1.32), C.I (25.00), porosity (70.00), hydration, swelling and moisture sorption capacities (4.00, 47.16, 21.30). The DSC showed a sharp peak at 73⁰C which depicts high purity. Both MCCs showed the same organoleptic properties, similar DSC and also had poor flowability. Overall, the results indicated that SO-MCC compared favourably with commercial grade Avicel PH 102 in terms of its physico-chemical properties(P<0.05) and complied with British Pharmacopoeia specifications for microcrystalline cellulose.