Preparation and Comparative Evaluation of Physicochemical Properties of Microcrystalline Cellulose Derived from Saccharum officinarum L (Poaceae) with Avicel(R) PH102
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Abstract
Bu çalışmanın amacı, SO-MCC kodlu şeker kamışının (Saccharum officinarum) kurutulmuş kök küspesinden elde edilen yerel olarak hazırlanmış bir mikrokristalin selülozun hazırlanması ve fizikokimyasal özelliklerinin ticari kalite (Avicel PH 102) ile karşılaştırılmasıdır. SO-MCC, kurutulmuş şeker kamışı sapı yongalarından alkali hidroliz yoluyla türetilen, sodyum hipoklorit ile ağartılmış ve 2.5N hidroklorik asit ile muamele edilmiş selülozdan hazırlanmıştır. MCC, BP (2009) yöntemiyle tanımlandı. Değerlendirilen karşılaştırmalı fizikokimyasal özellikler şunları içerir: DSC, pH, ortalama partikül çapı, gerçek, yığın ve kademeli yoğunluklar, durma açısı, Hausner bölümü, sıkıştırılabilirlik indeksi, gözeneklilik, hidrasyon, şişme ve nem emme kapasiteleri. Bu testlerden elde edilen sonuçlar: pH (7.5), ortalama parçacık çapı (239), gerçek, yığın ve kılavuzlu yoğunluklar (1.54, 0.464, 0.617), durma açısı (34.70), Hausner bölümü (1.32), CI (25.00) ), gözeneklilik (70.00), hidratasyon, şişme ve nem emme kapasiteleri (4.00, 47.16, 21.30). DSC, 730°C'de yüksek saflığı gösteren keskin bir tepe gösterdi. Her iki MCC de aynı organoleptik özellikleri, benzer DSC'yi gösterdi ve ayrıca zayıf akışkanlığa sahipti. Genel olarak, sonuçlar SO-MCC'nin fiziko-kimyasal özellikleri açısından ticari sınıf Avicel PH 102 ile olumlu bir şekilde karşılaştırıldığını ve mikrokristalin selüloz için İngiliz Farmakopesi spesifikasyonlarına uyduğunu gösterdi.
Keywords
Abstract
This study was aimed at preparation and comparison of the physiochemical properties of a locally prepared microcrystalline cellulose obtained from dried stem pulp chips of sugarcane (Saccharum officinarum) coded SO-MCC and compared with a commercial grade (Avicel PH 102). SO-MCC was prepared from a-cellulose derived by alkaline hydrolysis from dried sugarcane stem chips, bleached with sodium hypochlorite and treated with 2.5N hydrochloric acid. The MCC were identified by BP (2009) method. The comparative physicochemical properties evaluated include: DSC, pH, mean particles diameter, true, bulk and tapped densities, angle of repose, Hausner’s quotient, compressibility index, porosity, hydration, swelling and moisture sorption capacities. The results obtained from these tests are: pH (7.5), mean particle diameter (239), true, bulk and tapped densities (1.54, 0.464, 0.617), angle of repose (34.70), Hausner’s quotient (1.32), C.I (25.00), porosity (70.00), hydration, swelling and moisture sorption capacities (4.00, 47.16, 21.30). The DSC showed a sharp peak at 730C which depicts high purity. Both MCCs showed the same organoleptic properties, similar DSC and also had poor flowability. Overall, the results indicated that SO-MCC compared favourably with commercial grade Avicel PH 102 in terms of its physico-chemical properties(P<0.05) and complied with British Pharmacopoeia specifications for microcrystalline cellulose.
Keywords
- [1] F.O. Ohwoavworhua, T.A. Adelakun, A.O. Okhamafe, “Processing pharmaceutical grade microcrystallinecellulose from groundnut husk: Extraction methods and characterization”. International Journal of Green Pharmacy, vol. 3, no 2, pp.97 – 104, 2009.
- [2] R.D. Roro, H.S. Sutriyo, “Preparation and characterization of microcrystalline cellulose produced from BetungBamboo (Dendrocalamus asper) through Acid Hydrolysis”. J. Young Pharm, vol. 10, no.2, pp. 578-583, 2018.
- [3] F.O. Ohwoavworhua, S.I. Ofoefule, “Evaluation of the Disintegrant Properties of microcrystalline celluloseobtained from Luffa cylindrica in Aspirin-based formulations,” African J. Pharm. Res. Dev. vol 2, no.1, pp. 54- 59, 2006
- [4] F.O. Ohwoavworhua, T.A. Adelakun, “Some physical characteristics of microcrystalline cellulose obtainedfrom Raw cotton of Cochlospermum planchonii,” Tropical Journal of Pharmaceutical research, vol. 4, no. 2; pp.501-507, 2005.
- [5] O.N.C. Umeh, A.C. Nworah, S.I. Ofoefule. “Physicochemical properties of microcrystalline cellulose derived from Indian Bamboo (Bambusa vulgaris),” Int. J. Pharm. Sci. Rev. Res, vol. 29, no.2, pp.5-9, 2014.
- [6] M.L. Hassan, M. El-Sakhawy, “Physical and mechanical properties of microcrystalline cellulose prepared fromlocal Agricultural Residues”, presented at 8th Arab International Conference on polymer science technology, Cairo, Egypt, 2005.
- [7] D.K. Ranjan, N. Yuhka, E.O. Martins, K.B. Alak, “Extraction and characterization of microcrystalline cellulosefrom fodder grass; Setaria glauca (L) P. Beauv and its potential as a drug delivery vehicle for isoniazid, a first line antituberculosis drug,” Colloids and Surface B: Biointerfaces vol. 108, pp. 85-89, 2013.
- [8] M. Landin, R. Martinez Pacheco, A. Gomez, C. Souto, A. Conchero, R.C. Rowe, “Effect of batch variationand source of pulp on the properties of microcrystalline cellulose,” Int. J. Pharm, vol. 91, pp. 133-141, 1993.
- [9] L.D. Busari, S.M. Misari, G.O. Olaniyan, “Weed management systems in chewing cane production in theinland valleys of Nigeria,” presented at 16th Biennial Conference of Weed Science Society of Eastern Africa, Kampala, Uganda, 1997.
- [10] Y. Takeo, “Sugarcane,” in Encylcopedia Britannica [Online document], 2019. Available: Britannica Reference Online, https://www.britannica.com/plant/sugarcane [Accessed: February 27, 2022].
- [11] M. Adedokun, G. Essien, T. Uwah and C. Jackson, “Evaluation of the Release Properties of Microcrystallinecellulose derived from Saccharum officinarum L. in paracetamol Tablet formulation,” Journal of Pharmaceutical Sciences and research, vol. 6, no. 10, pp. 342-346, 2014.
- [12] N. Nwachuckwu, K.C. Ugoeze, “Studies on Microsrystalline Cellulose obtained from Saccharumofficinarum: processing and Physicochemical properties,” European Journal of biomedical and pharmaceutical sciences, vol. 5, no. 2, pp. 42-48, 2018.
- [13] British Pharmacopoeia. The commission office London, vol. I and II, pp. 1694-1700, 2009.
- [14] C.H. Ansel, G.N. Popovich and V.I. Allen, Ansel: Pharmaceutical Dosage forms and Drug Delivery Systems. Lippincott Williams and Wilkins, New York, 2005, pp.189.
- [15] S.A. Chime, A.A. Attama, C.O. Agubata, J.D. Ogbonna and G.C. Onunkwo, “Micromeritic and antinoceptiveproperties of lyophilized indomethacin-loaded SLMs based on solidified reverse micellar solution,”J. Pharm. Res., vol. 5, no. 6, pp. 3410-3416, 2012.
- [16] D. Train, “Some aspects of the property of angle of repose of powders, J. Pharm. Pharmacology, vol. 10, pp. 127-134, 1958.
- [17] S.S. Kornblum and S.B. Stoopak, “A new tablet disintegrant agent crosslinked polyvinylpyrollidone,”J. Pharm. Sci. vol. 62, no. 1, pp. 43-49, 1973.
- [18] J.D. Audu-Peter, J.E. Ojile, P.G. Bhatia, “Physicochemical and powder properties of alpha and microcrystalline cellulose derived from maize cobs,” J. Pharm. Biores, vol. 1, no. 4, pp. 1-45, 2004.
- [19] A.M. Mohammed and E.J. Al-Akkam, “Formulation and evaluation of clopidogrel liquisolid compact,” Iraqi Journal of pharmaceutical sciences, vol. 27, no. 2, pp. 135-149, 2018.
- [20] W.E. Mazurek, K. Winnieka, K.A. Czajkowska, U. Czyzewska, W. Miltyk, “Application of differentialscanning calorimetry in evaluation of solid state interactions in tablets containing acetaminophen,” Acta Pol. Pharma. Vol. 70, no. 5, pp. 787-793, 2013.
- [21] M.E. Aulton, “Pharmaceutics: The Science of Dosage form Design,”3rd Edition, Churchill Livingstone, Edinburgh: 2007, pp-198-210.
- [22] C.P. Azubuike, B.O. Silva, A.O. Okhamafe, “Pharmacopoeial and physicochemical properties of -celluloseand microcrystalline cellulose powders derived from cornstalks”, International Journal of Green Pharmacy, vol. 6, no.1, pp. 93-98, 2012.
- [23] J.N. Staniforth, “Powder flow,” in Pharmaceutics, M. Aulton. The science of Dosage form Design, Churchill Livingstone: 1996, pp-600-615.
- [24] I.V. Onyishi, S.A. Chime, C.A. Okoroji, “physicochemical properties of microcrystalline cellulose fromSaccharum officinarum: Comparative Evaluation with Avicel PH101,” American Journal of Pharm. Tech Research, vol. 3, no. 5, pp. 415-426, 2013.
- [25] L. Lachman, A. Herbert and J. Lieberman, “The theory and practice of Industrial Pharmacy” Mumbai: 1990, pp-318-320.
- [26] J.N. Oraeluno, J.C. Obasi, E.A. Bamigbola, B.A. Joseph, “Production and Evaluation of DisintegrantProperties of microcrystalline cellulose derived from Saccharum officinarum L (Poaceae) in metronidazole based formulation,” International Journal of Pharmaceutical Science and Medicine, vol. 6, no. 4, pp. 42-51, 2021.
- [27] C.Caramela, “Novel methods for disintegrants characterization,” part 1, Pharm. Technol, pp. 48-55, 1991. [28] A.F. Stamm, Wood and Cellulose Science. New York: The Ronald Press, 1964.
